Società Italiana di Biofisica e Biologia Molecolare
Società Italiana di Biofisica e Biologia Molecolare
SIBBM 2026 • Frontiers in Molecular Biology
SIBBM 2026 • Frontiers in Molecular Biology
Molecular Mechanisms of Cell Response to Biological Sensing
Molecular Mechanisms of Cell Response to Biological Sensing
Siena, Italy · 16-18 June 2026
Siena, Italy · 16-18 June 2026
Società Italiana di Biofisica e Biologia Molecolare
SIBBM 2026 • Frontiers in Molecular Biology
Molecular Mechanisms of Cell Response to Biological Sensing
Siena, Italy · 16-18 June 2026
| 13:00-14:00 | Light lunch and registration |
| 14:00-14:15 | Welcome address |
|
Session I - Gene response to cell sensing (Joint Session with Association of Cell Biology and Differentiation-ABCD) CHAIRS: Simona Paladino (University of Naples) and Elvira Parrotta (Magna Graecia University of Catanzaro) |
|
| 14:15-14:45 |
Stefano Piccolo (University of Padua, Italy) 3D Blueprints of malignancies |
| 14:45-15:15 |
Alessandro Prigione (Heinrich Heine University, Düsseldorf, Germany) Accelerating mitochondrial disease treatments with brain organoid models |
| 15:15-15:45 |
Elena Taverna (Human Technopole, Milan, Italy) Choosing to be different: mapping neural stem cell fate to organelle functions |
| 15:45-16:00 |
Roberto Quadri (Milan, Italy) A Haspin-Fab1 axis modulates TORC1 localization and activity in budding yeast |
| 16:00-16:15 |
Anna Pepe (Paris, France) Tunneling nanotubes provide a route for SARS-CoV-2 spreading |
| 16:15-16:45 | Coffee break |
| 16:45-17:00 |
Francesca Guarino (Catania, Italy) Extended promoter architecture governs VDAC3 expression: insights into mitochondrial gene regulation and oxidative stress sensing |
| 17:00-17:15 |
Laura Talarico (Pisa, Italy) Promoting neural stem cell maturation via mechanical forces for next-generation neurodegenerative disease therapies |
| 17:15-17:30 |
Companies’ corner Pierluigi Tenca (Sales Manager, Tema Ricerca Srl) SeekOne™ Multiomics: DNA Methylation + RNA-seq at Single-Cell |
| 17:30-19:30 | AperiPoster Session I (odd numbers) |
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Session II - RNA-based Regulation and Plasticity CHAIRS: Monica Ballarino (Sapienza University of Rome) and Francesco Nicassio (IIT, Milan) |
|
| 9:00-9:30 |
Sandra Blanco (CIC-IBMCC, University of Salamanca, Spain) Targeting RNA methylases in cancer therapy: a novel approach to revolutionize treatment |
| 9:30-10:00 |
Maite Huarte (CIMA - Universidad de Navarra, Spain) Control of genomic stability by noncoding RNA |
| 10:00-10:30 |
Luca Pandolfini (Istituto Italiano di Tecnologia, Genoa, Italy) From genome to brain: decoding nervous system development through functional multi-omics |
| 10:30-10:45 |
Giuseppina Covello (Padua, Italy) Rewiring tau splicing in FTDP-17 through targeted exon 10 skipping |
| 10:45-11:00 |
Sara Milioni (Turin, Italy) Targeting the m6A pathway in ALK-driven anaplastic large cell lymphoma |
| 11:00-11:30 | Coffee break |
| 11:30-11:45 |
Lorenzo Vaccaro (Pozzuoli, NA, Italy) Genotype-phenotype single-cell transcriptomics for massive parallel assessment of genetic variants |
| 11:45-12:00 |
Paolo Gandellini (Milan, Italy) Characterization of NFYA 3′UTR landscape reveals alternative polyadenylation as a targetable vulnerability in prostate cancer |
| 12:00-12:15 |
Pietro Laneve (Rome, Italy) The dark side of Medulloblastoma |
| 12:15-12:30 |
Fabio Piscopo (Rome, Italy) Targeting METTL3 induces homologous recombination defects and sensitizes tumors to PARP inhibition across solid cancers |
| 12:30-12:45 |
Companies’ corner Raffaele Ricci (Promega Italia s.r.l.) Bioluminescence as a readout for biologics: from molecular interactions to cellular efficacy |
| 12:45-14:00 | Lunch |
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Session III - Biologics as therapeutics CHAIRS: Jamie Hackett (European Molecular Biology Laboratory) and Vittoria Raffa (University of Pisa) |
|
| 14:00-14:30 |
EMBL Lecture Luigi Naldini (San Raffaele Telethon Institute for Gene Therapy, Milan, Italy) Advanced genetic engineering of hematopoiesis as therapeutic |
| 14:30-15:00 |
Stefano Gustincich (Istituto Italiano di Tecnologia, Genoa, Italy) SINEUPs as a new class of lncRNAs enhancing translation |
| 15:00-15:30 |
Riccardo Cortese Lecture Cosima Tatiana Baldari (University of Siena, Italy) Supramolecular attack particles (SMAPs): a new weapon of the CTL killing arsenal that can be tailored for cancer cell targeting |
| 15:30-15:45 |
Guglielmo Bove (Naples, Italy) METTL16-mediated inhibition of MXD4 promotes acute myeloid leukemia through activation of MYC-MAX axis |
| 15:45-16:00 |
Stella Nappi (Siena, Italy) A novel class of proteinaceous particles as both therapeutic targets and delivery platforms for glioblastoma treatment |
| 16:00-16:30 |
Isabel Delany (GSK Vaccines, Siena, Italy) Isolation of human monoclonal antibodies from 4CmenB vaccinees identifies meningococcal antigens that confer cross-protection against gonococcus |
| 16:30-18:30 | AperiPoster Session II (even numbers) |
| 19:30 | Social dinner |
| 9:00-10:00 | SIBBM members’ general assembly |
|
Session IV - Cutting edges in DNA replication CHAIRS: Marco Muzi Falcone (University of Milan) and Francesca Pisani (IBBC - CNR, Naples) |
|
| 10:00-10:30 |
Roberto Bellelli (Barts Cancer Institute, Queen Mary University of London, UK) The genetic and biochemical basis of human leading strand synthesis |
| 10:30-11:00 |
Julian Sale (MRC Laboratory of Molecular Biology, Cambridge, UK) Determinants of the pattern of DNA replication |
| 11:00-11:30 | Coffee break |
| 11:30-11:45 |
Federico Lazzaro (Milan, Italy) An RNA-extension activity of pol η contributes to the resolution of transcription–replication conflicts during HU-induced replication stress |
| 11:45-12:00 |
Marco Russo (Bologna, Italy) Top1cc-driven genome instability imprints distinct indel and structural variant signatures in colorectal cancer |
| 12:00-12:15 |
Ylenia Martinini (Florence, Italy) Dysregulation of centrosomal protein STARD9 as a novel therapeutic vulnerability in ER+ breast cancer |
| 12:15-12:30 |
Alessandro Restellini (Milan, Italy) Genome-scale cancer dependency maps reveal specific vulnerabilities in MYCL-amplified small cell lung cancer |
| 12:30-13:00 |
Aga Gambus (University of Birmingham, UK) CDK-driven phosphorylation of TRAIP ubiquitin ligase is essential for mitotic replisome disassembly and mitotic DNA synthesis (MiDAS) |
| 13:00-13:15 | Prizes and wrap-up |
The poster's maximum size is A0 (841 x 1189 mm; width x height).
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Posters with an odd number will be presented during Poster Session 1 (Tuesday, 16 June, 17:30-19:30). Posters with an even number will be presented during Poster Session 2 (Wednesday, 17 June, 16:30-18:30). All posters should stay up for the entire duration of the meeting, independently of the session to which they have been assigned.
P.1 Natalia Abate, Naples
A novel molecular mechanism driven by Cystatin B during early stages of human neuronal development
P.2 Nicole Annesi, Trento
Turning TRPM8 and PSMA against prostate cancer by exploiting convergent lethality
P.3 Ylenia Antonacci, Bari
Novel strategies to reactivate p53 and overcome drug resistance in tumors
P.4 Chiara Barone, Naples
REP-1 deficiency induces aberrant mitochondrial metabolic rewiring from glycolysis to lipid oxidation in CHM disease
P.5 Marina Benítez Ramos, Trento
Identifying RNA Binding Protein regulators of TIGIT expression in Natural Killer
cells
P.6 Maxim Bouvet, Turin
TGS1-mediated 5’ cap trimethylation regulates translation of target mRNAs in AML
P.7 Maria Giusy Bruno, Verona
Unraveling the role of PTBP1 in regulating alternative splicing of MAPT in a
patient-derived midbrain organoid model of Parkinson's disease
P.8 Alessandra Caliendo, Naples
A CD44 aptamer-guided therapeutic strategy to block crosstalk between tumor cells and tumor-associated macrophages in chemoresistant triple-negative breast cancer
P.9 Alessia Campese, Verona
N-Glycosylation modulates receptor binding and neutralization sensitivity of Influenza A H5N1 hemagglutinin
P.10 Marta Cantarelli, Povo, TN
Development of flexible heterotypic 3D models for live imaging study of anti-tumor immune strategies in prostate cancer
P.11 Mauro Caprioli, Verona
Adipose mesenchymal stem cell-derived extracellular vesicles as potential therapeutic biologic agents for damaged motoneurons in Amyotrophic Lateral Sclerosis
P.12 Roberta Caschetto, Catania
Identification of a novel functional axis SLC-VDAC for Glioblastoma multiforme potential treatment
P.13 Maria Carmela Cavallo, Siena
SupraMolecular Attack Particles (SMAPs): a new weapon against virus-infected cells
P.14 Marianna Ciuffreda, Trento
Exploring the transcriptome of Pediatric Myelodysplastic Syndrome (PMDS)
P.15 Sara Cozzubbo, Turin
miR-214-driven-MFN2-downregulation promotes mitochondria dysfunction and it affects melanoma progression
P.16 Marco Crepaldi, Naples
Establishing METTL16 as a key regulator of GBM carcinogenesis
P.17 Angelo D'Angelo, Rome
Neuronal late endosomes serve as selective RNA hubs disrupted by ALS-linked FUS mutation
P.18 Fabrizio Damiano, Lecce
Pirin as a novel therapeutic target in hepatocellular carcinoma through modulation of the BCL3–tmTNF-α juxtacrine signaling axis
P.19 Pierpaolo De Iaco, Florence
The role of ERG transcription factor in the modulation of immuno-regulatory protein CD47
P.20 Alessio De Magis, Milan
HMGB1 regulates nuclear properties and cell migration through Lamin A/C transcriptional modulation
P.21 Carola De Martinis, Verona
Functional interplay between ACOT8 and Nef enhances HIV-1 infectivity and remodels the viral envelope
P.22 Gaia De Rigo, Padua
Identification of bioactive compounds activating Mtf1
P.23 Rosa De Santis, Naples
Reprogramming-to-organoids: how to cost-efficiently leverage hIPSCs to model human diseases
P.24 Veronica De Vita, Verona
EGFR ligand Angiogenin predicts response to TGFβ Inhibition in Pancreatic Cancer via a TNF-α Paracrine Axis in Tumor-Associated Macrophages
P.25 Martina Di Bartolomeo, Teramo
Prenatal exposure to THC and CBD alters endocannabinoid and dopaminergic gene expression in the rat prefrontal cortex: epigenetic insights across preadolescence and adolescence
P.26 Daniela Di Girolamo, Naples
ASO-mediated p63 isoform switching as therapeutic strategy for AEC syndrome
P.27 Daniele Durante, Rome
Inside and beyond muscle: lncRNA-mediated regulation of intrinsic myogenic programs and paracrine crosstalk
P.28 Claudia Esposito, Catanzaro
Cannabidiol effect on preventing Parkinson’s Disease pathogenesis in iPSC-derived dopaminergic neurons from sporadic patients
P.29 Luigi Fattore, Rome
OncomiR-driven metastatic phenotype associates with chromatin changes in drug-resistant melanoma
P.30 Beatrice Feliciani, Teramo
Integrative epigenetic analysis of BDNF: PBMC DNA methylation and salivary miRNA expression in bipolar disorder
P.31 Daniela Fignani, Siena
ISG20 as a key exoribonuclease driving inflammation-induced 3′end miRNA trimming in pancreatic β-cells
P.32 Ermes Filomena, Bari
Human neural stem cell fate is controlled by the alternative splicing regulator PTBP1
P.33 Bruno Fosso, Bari
Assessing gut microbiome health using integrative omics data analysis and machine learning
P.34 Lorenzo Franci, Siena
MAPK15 regulates iron homeostasis through modulation of IRP2 stability
P.35 Gaia Fusto, Catania
Regulatory landscape of VDAC1: integrating metabolic and transcriptional signals in cancer
P.36 Matteo Gatta, Siena
Indirect mechanisms of T cell and CAR T cell suppression by SARS-CoV-2 in patients with classical Hodgkin
lymphoma
P.37 Antonio Grimaldi, Pozzuoli, NA
Title Integrated multi-omics reveals tissue-specific host–microbiome interactions and cross-site microbial signatures in pediatric IBD and FGID
P.38 Aymone Gurtner, Rome
Deciphering the crosstalk between miR-200C and NF-YA splicing in cancer cells
P.39 Ciro Iaccarino, Sassari
The TDP43-ASRGL1 functional interaction governs the progression of neurodegeneration in Drosophila
P.40 Domenico Ignoti, Turin
Metabolic CRISPR Screen Identifies Novel Synthetic Lethal Partner of TGS1 in Acute Myeloid Leukemia
P.41 Giuliana La Rosa, Naples
Capturing extracellular vesicles (EVs) in human ventral midbrain organoids
P.42 Joshua Levendis, Parkville, Australia
The RNA modification m6A facilitates poly-adenylation in the malaria parasite Plasmodium falciparum
P.43 Nicolò Magri, Padua
GP130 signalling modulates the differentiation potential of naive human pluripotent stem cells
P.44 Federico Marchini, Siena
EGLN1 stabilizes NRF2 to coordinate metabolism and oxidative stress
P.45 Elisa Marmocchi, Povo, TN
Overcoming prostate cancer "coldness": a combinatorial approach using standard treatments and OMV-based vaccines
P.46 Stefania Martucciello, Fisciano, SA
Interaction between Tbx1 and Vegfr3 in cardiac morphogenesis
P.47 Giacomo Menichetti, Verona
RBM20 is a novel regulator of alternative splicing in a neuronal model
P.48 Gianluca Mordini, Rome
Exploring the regulative role of the long non-coding RNA AC064875.1 in Glioblastoma stem cells and its therapeutic potential
P.49 Maria Chiara Mottola, Pavia
Comprehensive isoform landscape of the LINP1 locus in LigI-defective fibroblasts under chronic DNA damage
P.50 Marco Muzi Falconi, Milan
Vid22 counteracts G-quadruplex-induced genome instability
P.51 Gaia Nicotra, Catania
Phytochemical-induced epigenetic reprogramming and cellular sensing: multi-omics dissection of Broccolo nero leaf extracts across developmental stages
P.52 Sabela Nikolli, Rome
Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53/Dicer complex
P.53 Erika Pascale, Naples
WNT signaling activation promotes dopaminergic differentiation toward A10 fate
P.54 Graziano Pesole, Bari
Machine learning-based assessment of the healthy human gut mycobiota landscape using ITS1 DNA metabarcoding data
P.55 Fabio Petti, Rome
Unraveling the role of the lncRNA MALAT1 in keratinocyte physiopathology
P.56 Alessandra Ruggiero, Verona
Abrogation of specific glycosylation sites on SARS-CoV2 Spike enhance virus infectivity and modulate antibody neutralizing activity
P.57 Alessandra Saitta, Messina
Elucidating the role of GAT3 in Alzheimer’s disease
P.58 Michele Sallese, Chieti
Methylomic profiling to uncover the pathological mechanisms of Marinesco–Sjögren syndrome
P.59 Marcello Salvi, Pozzuoli, NA
A multi-omic atlas of transcription factor regulatory grammar in human fibroblasts
P.60 Alfredo Sepe, Padua
miRNA-mediated targeting of LSD1 and PRMT6 as a novel strategy to modulate androgen receptor signaling
P.61 Marco Simula, Rome
Modeling early neuromuscular co-development: A 3D Neuromuscular organoids platform to unveil lncRNA dynamics in lineage bifurcation
P.62 Mariagrazia Talarico, Catanzaro
Blocking the TGF-β pathway attenuates neurodegeneration and tau pathology in a model of progressive supranuclear palsy
P.63 Gabriele Tani, Florence
CYP1A1 regulates estrogen receptor activity and response to CDK4/6 inhibitors in estrogen receptor-positive breast cancer cells
P.64 Angela Toffano, Padua
Gene therapy in Huntington’s disease: functional validation through early phenotype rescue and multi-omics profiling
P.65 Asia Trano, Naples
Compartmentalized control of Cdk1 activity drives mitosis exit
P.66 Apollonia Tullo, Bari
Integrated epigenetic and transcriptional profiling reveals microenvironment-dependent plasticity in pancreatic cancer models
P.67 Danila Valletta, Caserta
MiR-15b-5p: a newly identified tumor suppressor in colorectal adenocarcinoma
P.68 Antonia Voli, Fisciano, SA
Modelling early pre-cancerous stages in vitro using human gastric organoids and mucosoids
P.69 Minxing Zhang, Paris, France
Impact of SARS-CoV-2 infection on neurodegeneration