Società Italiana di Biofisica e Biologia Molecolare

Società Italiana di Biofisica e Biologia Molecolare

SIBBM 2026 • Frontiers in Molecular Biology

SIBBM 2026 • Frontiers in Molecular Biology

Molecular Mechanisms of Cell Response to Biological Sensing

Molecular Mechanisms of Cell Response to Biological Sensing

Siena, Italy · 16-18 June 2026

Siena, Italy · 16-18 June 2026

Società Italiana di Biofisica e Biologia Molecolare

SIBBM 2026 • Frontiers in Molecular Biology

Molecular Mechanisms of Cell Response to Biological Sensing

Siena, Italy · 16-18 June 2026

Programme

Programme

  • 13:00-14:00 Light lunch and registration
    14:00-14:15 Welcome address
    Session I - Gene response to cell sensing (Joint Session with Association of Cell Biology and Differentiation-ABCD)
    CHAIRS: Simona Paladino (University of Naples) and Elvira Parrotta (Magna Graecia University of Catanzaro)
    14:15-14:45 Stefano Piccolo  (University of Padua, Italy)
    3D Blueprints of malignancies
    14:45-15:15 Alessandro Prigione (Heinrich Heine University, Düsseldorf, Germany)
    Accelerating mitochondrial disease treatments with brain organoid models
    15:15-15:45 Elena Taverna (Human Technopole, Milan, Italy)
    Choosing to be different: mapping neural stem cell fate to organelle functions
    15:45-16:00 Roberto Quadri (Milan, Italy)
    A Haspin-Fab1 axis modulates TORC1 localization and activity in budding yeast
    16:00-16:15 Anna Pepe (Paris, France)
    Tunneling nanotubes provide a route for SARS-CoV-2 spreading
    16:15-16:45 Coffee break
    16:45-17:00 Francesca Guarino (Catania, Italy)
    Extended promoter architecture governs VDAC3 expression: insights into mitochondrial gene regulation and oxidative stress sensing
    17:00-17:15 Laura Talarico (Pisa, Italy)
    Promoting neural stem cell maturation via mechanical forces for next-generation neurodegenerative disease therapies
    17:15-17:30 Companies’ corner
    Pierluigi Tenca (Sales Manager, Tema Ricerca Srl)
    SeekOne™ Multiomics: DNA Methylation + RNA-seq at Single-Cell
    17:30-19:30 AperiPoster Session I (odd numbers)
  • Session II - RNA-based Regulation and Plasticity
    CHAIRS: Monica Ballarino (Sapienza University of Rome) and Francesco Nicassio (IIT, Milan)
    9:00-9:30 Sandra Blanco (CIC-IBMCC, University of Salamanca, Spain)
    Targeting RNA methylases in cancer therapy: a novel approach to revolutionize treatment
    9:30-10:00 Maite Huarte (CIMA - Universidad de Navarra, Spain)
    Control of genomic stability by noncoding RNA
    10:00-10:30 Luca Pandolfini (Istituto Italiano di Tecnologia, Genoa, Italy)
    From genome to brain: decoding nervous system development through functional multi-omics
    10:30-10:45 Giuseppina Covello (Padua, Italy)
    Rewiring tau splicing in FTDP-17 through targeted exon 10 skipping
    10:45-11:00 Sara Milioni (Turin, Italy)
    Targeting the m6A pathway in ALK-driven anaplastic large cell lymphoma
    11:00-11:30 Coffee break
    11:30-11:45 Lorenzo Vaccaro (Pozzuoli, NA, Italy)
    Genotype-phenotype single-cell transcriptomics for massive parallel assessment of genetic variants
    11:45-12:00 Paolo Gandellini (Milan, Italy)
    Characterization of NFYA 3′UTR landscape reveals alternative polyadenylation as a targetable vulnerability in prostate cancer
    12:00-12:15 Pietro Laneve (Rome, Italy)
    The dark side of Medulloblastoma
    12:15-12:30 Fabio Piscopo (Rome, Italy)
    Targeting METTL3 induces homologous recombination defects and sensitizes tumors to PARP inhibition across solid cancers
    12:30-12:45 Companies’ corner
    Raffaele Ricci (Promega Italia s.r.l.)
    Bioluminescence as a readout for biologics: from molecular interactions to cellular efficacy
    12:45-14:00 Lunch
    Session III - Biologics as therapeutics
    CHAIRS: Jamie Hackett (European Molecular Biology Laboratory) and Vittoria Raffa (University of Pisa)
    14:00-14:30 EMBL Lecture
    Luigi Naldini (San Raffaele Telethon Institute for Gene Therapy, Milan, Italy)
    Advanced genetic engineering of hematopoiesis as therapeutic
    14:30-15:00 Stefano Gustincich (Istituto Italiano di Tecnologia, Genoa, Italy)
    SINEUPs as a new class of lncRNAs enhancing translation
    15:00-15:30 Riccardo Cortese Lecture
    Cosima Tatiana Baldari (University of Siena, Italy)
    Supramolecular attack particles (SMAPs): a new weapon of the CTL killing arsenal that can be tailored for cancer cell targeting
    15:30-15:45 Guglielmo Bove (Naples, Italy)
    METTL16-mediated inhibition of MXD4 promotes acute myeloid leukemia through activation of MYC-MAX axis
    15:45-16:00 Stella Nappi (Siena, Italy)
    A novel class of proteinaceous particles as both therapeutic targets and delivery platforms for glioblastoma treatment
    16:00-16:30 Isabel Delany (GSK Vaccines, Siena, Italy)
    Isolation of human monoclonal antibodies from 4CmenB vaccinees identifies meningococcal antigens that confer cross-protection against gonococcus
    16:30-18:30 AperiPoster Session II (even numbers)
    19:30 Social dinner
  • 9:00-10:00 SIBBM members’ general assembly
    Session IV - Cutting edges in DNA replication
    CHAIRS: Marco Muzi Falcone (University of Milan) and Francesca Pisani (IBBC - CNR, Naples)
    10:00-10:30 Roberto Bellelli (Barts Cancer Institute, Queen Mary University of London, UK)
    The genetic and biochemical basis of human leading strand synthesis
    10:30-11:00 Julian Sale (MRC Laboratory of Molecular Biology, Cambridge, UK)
    Determinants of the pattern of DNA replication
    11:00-11:30 Coffee break
    11:30-11:45 Federico Lazzaro (Milan, Italy)
    An RNA-extension activity of pol η contributes to the resolution of transcription–replication conflicts during HU-induced replication stress
    11:45-12:00 Marco Russo (Bologna, Italy)
    Top1cc-driven genome instability imprints distinct indel and structural variant signatures in colorectal cancer
    12:00-12:15 Ylenia Martinini (Florence, Italy)
    Dysregulation of centrosomal protein STARD9 as a novel therapeutic vulnerability in ER+ breast cancer
    12:15-12:30 Alessandro Restellini (Milan, Italy)
    Genome-scale cancer dependency maps reveal specific vulnerabilities in MYCL-amplified small cell lung cancer
    12:30-13:00 Aga Gambus (University of Birmingham, UK)
    CDK-driven phosphorylation of TRAIP ubiquitin ligase is essential for mitotic replisome disassembly and mitotic DNA synthesis (MiDAS)
    13:00-13:15 Prizes and wrap-up
  • The poster's maximum size is A0 (841 x 1189 mm; width x height).

    Correct format... poster should be PORTRAIT  poster should NOT be LANDSCAPE Wrong format...

    Posters with an odd number will be presented during Poster Session 1 (Tuesday, 16 June, 17:30-19:30). Posters with an even number will be presented during Poster Session 2 (Wednesday, 17 June, 16:30-18:30). All posters should stay up for the entire duration of the meeting, independently of the session to which they have been assigned.

    P.1 Natalia Abate, Naples
    A novel molecular mechanism driven by Cystatin B during early stages of human neuronal development

    P.2 Nicole Annesi, Trento
    Turning TRPM8 and PSMA against prostate cancer by exploiting convergent lethality

    P.3 Ylenia Antonacci, Bari
    Novel strategies to reactivate p53 and overcome drug resistance in tumors

    P.4 Chiara Barone, Naples
    REP-1 deficiency induces aberrant mitochondrial metabolic rewiring from glycolysis to lipid oxidation in CHM disease

    P.5 Marina Benítez Ramos, Trento
    Identifying RNA Binding Protein regulators of TIGIT expression in Natural Killer cells

    P.6 Maxim Bouvet, Turin
    TGS1-mediated 5’ cap trimethylation regulates translation of target mRNAs in AML

    P.7 Maria Giusy Bruno, Verona
    Unraveling the role of PTBP1 in regulating alternative splicing of MAPT in a patient-derived midbrain organoid model of Parkinson's disease

    P.8 Alessandra Caliendo, Naples
    A CD44 aptamer-guided therapeutic strategy to block crosstalk between tumor cells and tumor-associated macrophages in chemoresistant triple-negative breast cancer

    P.9 Alessia Campese, Verona
    N-Glycosylation modulates receptor binding and neutralization sensitivity of Influenza A H5N1 hemagglutinin

    P.10 Marta Cantarelli, Povo, TN
    Development of flexible heterotypic 3D models for live imaging study of anti-tumor immune strategies in prostate cancer

    P.11 Mauro Caprioli, Verona
    Adipose mesenchymal stem cell-derived extracellular vesicles as potential therapeutic biologic agents for damaged motoneurons in Amyotrophic Lateral Sclerosis

    P.12 Roberta Caschetto, Catania
    Identification of a novel functional axis SLC-VDAC for Glioblastoma multiforme potential treatment

    P.13 Maria Carmela Cavallo, Siena
    SupraMolecular Attack Particles (SMAPs): a new weapon against virus-infected cells

    P.14 Marianna Ciuffreda, Trento
    Exploring the transcriptome of Pediatric Myelodysplastic Syndrome (PMDS)

    P.15 Sara Cozzubbo, Turin
    miR-214-driven-MFN2-downregulation promotes mitochondria dysfunction and it affects melanoma progression

    P.16 Marco Crepaldi, Naples
    Establishing METTL16 as a key regulator of GBM carcinogenesis

    P.17 Angelo D'Angelo, Rome
    Neuronal late endosomes serve as selective RNA hubs disrupted by ALS-linked FUS mutation

    P.18 Fabrizio Damiano, Lecce
    Pirin as a novel therapeutic target in hepatocellular carcinoma through modulation of the BCL3–tmTNF-α juxtacrine signaling axis

    P.19 Pierpaolo De Iaco, Florence
    The role of ERG transcription factor in the modulation of immuno-regulatory protein CD47

    P.20 Alessio De Magis, Milan
    HMGB1 regulates nuclear properties and cell migration through Lamin A/C transcriptional modulation

    P.21 Carola De Martinis, Verona
    Functional interplay between ACOT8 and Nef enhances HIV-1 infectivity and remodels the viral envelope

    P.22 Gaia De Rigo, Padua
    Identification of bioactive compounds activating Mtf1

    P.23 Rosa De Santis, Naples
    Reprogramming-to-organoids: how to cost-efficiently leverage hIPSCs to model human diseases

    P.24 Veronica De Vita, Verona
    EGFR ligand Angiogenin predicts response to TGFβ Inhibition in Pancreatic Cancer via a TNF-α Paracrine Axis in Tumor-Associated Macrophages

    P.25 Martina Di Bartolomeo, Teramo
    Prenatal exposure to THC and CBD alters endocannabinoid and dopaminergic gene expression in the rat prefrontal cortex: epigenetic insights across preadolescence and adolescence

    P.26 Daniela Di Girolamo, Naples
    ASO-mediated p63 isoform switching as therapeutic strategy for AEC syndrome

    P.27 Daniele Durante, Rome
    Inside and beyond muscle: lncRNA-mediated regulation of intrinsic myogenic programs and paracrine crosstalk

    P.28 Claudia Esposito, Catanzaro
    Cannabidiol effect on preventing Parkinson’s Disease pathogenesis in iPSC-derived dopaminergic neurons from sporadic patients

    P.29 Luigi Fattore, Rome
    OncomiR-driven metastatic phenotype associates with chromatin changes in drug-resistant melanoma

    P.30 Beatrice Feliciani, Teramo
    Integrative epigenetic analysis of BDNF: PBMC DNA methylation and salivary miRNA expression in bipolar disorder

    P.31 Daniela Fignani, Siena
    ISG20 as a key exoribonuclease driving inflammation-induced 3′end miRNA trimming in pancreatic β-cells

    P.32 Ermes Filomena, Bari
    Human neural stem cell fate is controlled by the alternative splicing regulator PTBP1

    P.33 Bruno Fosso, Bari
    Assessing gut microbiome health using integrative omics data analysis and machine learning

    P.34 Lorenzo Franci, Siena
    MAPK15 regulates iron homeostasis through modulation of IRP2 stability

    P.35 Gaia Fusto, Catania
    Regulatory landscape of VDAC1: integrating metabolic and transcriptional signals in cancer

    P.36 Matteo Gatta, Siena
    Indirect mechanisms of T cell and CAR T cell suppression by SARS-CoV-2 in patients with classical Hodgkin 
    lymphoma

    P.37 Antonio Grimaldi, Pozzuoli, NA
    Title Integrated multi-omics reveals tissue-specific host–microbiome interactions and cross-site microbial signatures in pediatric IBD and FGID

    P.38 Aymone Gurtner, Rome
    Deciphering the crosstalk between miR-200C and NF-YA splicing in cancer cells

    P.39 Ciro Iaccarino, Sassari
    The TDP43-ASRGL1 functional interaction governs the progression of neurodegeneration in Drosophila

    P.40 Domenico Ignoti, Turin
    Metabolic CRISPR Screen Identifies Novel Synthetic Lethal Partner of TGS1 in Acute Myeloid Leukemia

    P.41 Giuliana La Rosa, Naples
    Capturing extracellular vesicles (EVs) in human ventral midbrain organoids

    P.42 Joshua Levendis, Parkville, Australia
    The RNA modification m6A facilitates poly-adenylation in the malaria parasite Plasmodium falciparum

    P.43 Nicolò Magri, Padua
    GP130 signalling modulates the differentiation potential of naive human pluripotent stem cells

    P.44 Federico Marchini, Siena
    EGLN1 stabilizes NRF2 to coordinate metabolism and oxidative stress

    P.45 Elisa Marmocchi, Povo, TN
    Overcoming prostate cancer "coldness": a combinatorial approach using standard treatments and OMV-based vaccines

    P.46 Stefania Martucciello, Fisciano, SA
    Interaction between Tbx1 and Vegfr3 in cardiac morphogenesis

    P.47 Giacomo Menichetti, Verona
    RBM20 is a novel regulator of alternative splicing in a neuronal model

    P.48 Gianluca Mordini, Rome
    Exploring the regulative role of the long non-coding RNA AC064875.1 in Glioblastoma stem cells and its therapeutic potential

    P.49 Maria Chiara Mottola, Pavia
    Comprehensive isoform landscape of the LINP1 locus in LigI-defective fibroblasts under chronic DNA damage

    P.50 Marco Muzi Falconi, Milan
    Vid22 counteracts G-quadruplex-induced genome instability

    P.51 Gaia Nicotra, Catania
    Phytochemical-induced epigenetic reprogramming and cellular sensing: multi-omics dissection of Broccolo nero leaf extracts across developmental stages

    P.52 Sabela Nikolli, Rome
    Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53/Dicer complex

    P.53 Erika Pascale, Naples
    WNT signaling activation promotes dopaminergic differentiation toward A10 fate

    P.54 Graziano Pesole, Bari
    Machine learning-based assessment of the healthy human gut mycobiota landscape using ITS1 DNA metabarcoding data

    P.55 Fabio Petti, Rome
    Unraveling the role of the lncRNA MALAT1 in keratinocyte physiopathology

    P.56 Alessandra Ruggiero, Verona
    Abrogation of specific glycosylation sites on SARS-CoV2 Spike enhance virus infectivity and modulate antibody neutralizing activity

    P.57 Alessandra Saitta, Messina
    Elucidating the role of GAT3 in Alzheimer’s disease

    P.58 Michele Sallese, Chieti
    Methylomic profiling to uncover the pathological mechanisms of Marinesco–Sjögren syndrome

    P.59 Marcello Salvi, Pozzuoli, NA
    A multi-omic atlas of transcription factor regulatory grammar in human fibroblasts

    P.60 Alfredo Sepe, Padua
    miRNA-mediated targeting of LSD1 and PRMT6 as a novel strategy to modulate androgen receptor signaling

    P.61 Marco Simula, Rome
    Modeling early neuromuscular co-development: A 3D Neuromuscular organoids platform to unveil lncRNA dynamics in lineage bifurcation

    P.62 Mariagrazia Talarico, Catanzaro
    Blocking the TGF-β pathway attenuates neurodegeneration and tau pathology in a model of progressive supranuclear palsy

    P.63 Gabriele Tani, Florence
    CYP1A1 regulates estrogen receptor activity and response to CDK4/6 inhibitors in estrogen receptor-positive breast cancer cells

    P.64 Angela Toffano, Padua
    Gene therapy in Huntington’s disease: functional validation through early phenotype rescue and multi-omics profiling

    P.65 Asia Trano, Naples
    Compartmentalized control of Cdk1 activity drives mitosis exit

    P.66 Apollonia Tullo, Bari
    Integrated epigenetic and transcriptional profiling reveals microenvironment-dependent plasticity in pancreatic cancer models

    P.67 Danila Valletta, Caserta
    MiR-15b-5p: a newly identified tumor suppressor in colorectal adenocarcinoma

    P.68 Antonia Voli, Fisciano, SA
    Modelling early pre-cancerous stages in vitro using human gastric organoids and mucosoids

    P.69 Minxing Zhang, Paris, France
    Impact of SARS-CoV-2 infection on neurodegeneration